Sports Medicine News

Caffeine, Genetics and Endurance Performance

Our results indicate that, in the total population, caffeine is ergogenic to cycling performance, with an average improvement in cycling time of 3 percent at a moderate dose (four milligrams per kilogram, roughly three small cups of coffee) — a finding that is consistent with previous studies using similar doses.

In addition, we found a significant caffeine–gene interaction where performance improvements with low and moderate caffeine doses reached almost 5 percent and 7 percent, respectively. However, these latter amplified benefits were seen only in the subjects with the AA genotype, i.e., those considered ‘‘fast’’ metabolizers of caffeine..


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